In the present research to exploit the opposite heterotic groups, potential heterotic boxes involving elite combiners were identified and these were exploited through reciprocal selection for combining ability. The experimental material was constituted by involving two diverse single cross F1s viz., DRGR-24-178 x DRGR-32-100 from High RGR (Relative growth rate) heterotic group and DSMR-10 x DSG3-5 from robust and stay green heterotic group which were identified as base populations. These crosses were advanced to F4 generation and 50 F4 lines of DRGR-24-178 x DRGR-32-100 and DSMR-10 x DSG3-5 were randomly selected and utilized in this study on reciprocal recurrent selection scheme. The crosses involving the F4 lines with opposite testers were referred to as derived F1s. The main objective of the present study was to identify the possible role of different traits contributing to the superiority and inferiority of genotypes by comparing their performances with the mean of all derived F1s and expressed as deviation from this group mean through path of productivity analysis. Top 20 potential derived F1s as well as bottom 20 derived F1s were considered for calculating the per cent deviation of genotypes from group mean. The path of productivity analysis among the top twenty derived F1s of both the population had positive value for seed cotton yield, lint yield, number of bolls per plant, boll weight, plant height, number of sympodia per plant, reproductive points on sympodia, inter boll distance, Ginning outturn (%) and lint index and results also indicated that top derived F1 from high RGR and robust/ stay green heterotic group had different paths to reach the desired levels of productivity.