A field experiment was conducted at College farm, PJTSAU, Rajendranagar, Hyderabad during 2014-2015 to evaluate effect of four sulphur levels (S1:-10 kg ha-1, S2:-20 kg ha-1, S3:-30 kg ha-1 and S4:-40 kg ha-1) and two methods of sulphur application (M1: 100% basal as single dose; M2: Two split applications: - 50% each at basal and knee heigh stage) in Quality Protein Maize (QPM) production using factorial randomised block design (FRBD). The results revealed that highest plant height, leaf area index (LAI), grain yield, stover yield, gross returns, net returns and benefit: cost ratio (B: C) were recorded with 40 kg S ha-1 as compared to 30 kg S ha-1, 20 kg S ha-1 and 10 kg S ha-1. Similarly, two methods of application split application of sulphur at basal and knee heigh stage shown maximum growth, yield parameters like number of rows per cob, number of grains per row, cob weight, grain weight, test weight, yield, harvest index, shelling percentage, protein content and economics compared with total basal application of sulphur. From the results it concluded that effect of the sulphur nutrient varies with the dose and its method of application. The right quantity and application at correct stage of the plant is important for growth and development of the plant. Application of sulphur @ 40 kg ha-1 along with split method of application can be recommended for sustaining productivity and profitability in quality protein maize.