This review outlined the allelopathic effects of Sesamum indicum in aqueous extract (A.E.) as well as in organic compounds i.e. Chloroform, Ethyl acetate, Hexane, Ethanol and Butanol at different concentration levels (1.0, 2.5, 5.0, 10.0, 20.0 and control) on germination and seedling growth of rice c.v. Kranti and its major weed Echinochloa column, in in-vitro and pot culture. However, treatments with higher concentrations had negative effects on mean rate of germination, plumule length and seedling dry weight. However, trend was found more toxic to weed (E. column) than rice seedlings. Organic extract of Sesamum indicum plant extract prepared in chloroform significantly reduced the germination and shoot length of E. column. S. indicum plant extracts applied as soil application at post emergence was found more toxic to E. column than rice cultivar on germination and seedlings growth. From practical point of view the identification of weeds with potential pool of allelochemicals and characterization of their adverse effects on germination of crops during early growth stages and finally on the commercial yield is highly recommended.