Rapid industrialization and overpopulation have stimulated increase in wastewater both domestic and industrial. Due to lack of inefficient sewerage system and absence of treatment plants, the wastewater is discharged into drainage systems causing environmental and health implications. At various points, the wastewater of these drains is used for irrigation purposes. This study characterizes the effluent of major drains of Nagpur city and assesses its suitability for irrigation. Temporal and spatial wastewater samples were collected from drains in rainy, winter and summer seasons during morning, afternoon and evening and analyzed for various parameters of special concern to irrigation. TSS, TDS, BOD, COD, N, P,EC , pH, micronutrient Zn, Mn, Cu and Fe Heavy metals Co, Cd ,Cr and Pb were found to be varied in concentration at different locations when compared with NEQS (National Environment Quality Standards) and FAO guidelines for irrigation in at different time and seasons. These results provide strong evidence that the water of these drains is not suitable for irrigation and other domestic purposes. Regular monitoring & proper treatment of wastewater before discharging into the drains can reduce the pollution in these drains.