A field experiment was carried out during kharif 2010 to study the effect of pre-emergence (Diclosulam 22g/ha, Oxyfluorfen 0.1kg/ha and Chlorimuron-p-ethyl 9g/ha) and post emergence (Imazethapyr 75 g/ha, Quizalofop-p-ethyl 75g/ha, Fenoxyprop-p-ethyl 75g/ha and Chlorimuron-p-ethyl 9g/ha) herbicides either alone or in sequence along with standard checks on weed control in soybean. Result revealed that sequential application of Oxyfluorfen 0.1kg/ha fb Imazethapyr 75g/ha and Diclosulam 22g/ha fb Imazethapyr 75 g/ha were quite effective in controlling weeds at 30 & 60 days as reflected in significantly lower weed count, dry matter, nutrients uptake and higher weed control index. Significantly higher soybean seed yield (27.21 and 25.96 q/ha, respectively) was also obtained in the same treatments. The growth (total dry matter, LAI and LAD) and yield (pods per plant, seed weight per plant and 100 seed weight) parameters followed the similar trend as that of seed yield. Higher net returns and B: C ratio were recorded with the application of Oxyfluorfen 0.1kg/ha fb Imazethapyr 75g/ha (` 41,030 ha-1 and 3.18) and Diclosulam 22g/ha fb Imazethapyr 75 g/ha (` 38,384 ha-1 and 3.05) than other treatments.