An experiment was laid out to evaluate the bio-safety of botanicals, microbial and conventional insecticide against egg, larval population of Chrysoperla and Lady bird bettle population. The average data on egg population of Chrysoperla was recorded to the tune of 2.05 and 2.18 eggs per plant in untreated control on 3 and 7 DAS, respectively followed by the treatment with other neem-based materials. The treatments with other botanicals were also relatively safer to egg population of Chrysoperla. While, the treatment with microbials appeared to be safer to the egg population against insecticidal treatments. The maximum larval population of Chrysoperla was observed in untreated control (0.96 and 0.60) on 3 and 7 DAS, respectively. The treatment with neem seed extract 5%, NSE 5% alternated with Btk @ 1000 ml/ha and neem oil 1 per cent has shown similar bio-safetyness as that of untreated control. While, the remaining treatments were also biosafer than that of the insecticidal treatment. As regard to the LBB adults population, the maximum population of LBB adults were recorded in untreated control to the extent of 2.29 and 2.37 adults per plant on 3 and 7 DAS, respectively, followed by the treatment with other neem-based material and the other botanicals were also appeared to be safer to LBB adults. Similarly, the treatment schedule of NSE 5 per cent alternated with either Btk @ 1000 ml/ha or HaNPV @250 LE/ha were also appeared to be safer to LBB adults. Regarding the field parasitization of H.armigera larvae, the untreated control shown the maximum larval parasitization (19.69%) and was found to be the most biosafer followed by the tretments with other neem-based material and microbial application. Whereas, the least parasitization was observed in the treatment with endosulfan 0.05 per cent (1.05%).