A field experiment was conducted for three years from 2008 to 2010 to study the effect of manurial liquids on microbial count, soil health and yield of wheat in Vertisol of central Vidarbha Zone of Maharashtra. Treatments includes inorganic fertilizers viz.,0, 50, 75 & 100 % RDF and manurial liquids viz., no manurial liquid, Amritpani, Panchagvya and vermiwash. Significant higher grain yield (23.69 tha-1) of wheat was recorded under application of 100% RDF with three spray of Amritpani. There were 13.83 % increases in grain yield as compared to 100 % RDF alone. Similarly, increases in yield to the tune of 9.24 to 21.67 % due to combination of manurial liquid with no RDF over control (no RDF+ no manorial liquid). Bacterial and actinomycetes count registered higher with low level of RDF whereas the fungi count (3.42 X 105 cfu/g of soil) recorded higher with increasing level of RDF. Higher N and P availability was noticed in Amritpani followed by panchagvya and vermiwash.