A field experiment was carried out during the rainy season (kharif) of 2005, 2006 and 2007 at ARS, Beechwal, Bikaner to study the effect of different agronomical practices on amelioration of drought stress in pearl millet (Pennisetum glaucum L.) under hyper arid region of Western Rajasthan. All the agronomical practices increase the grain yield significantly over the control plots. The highest grain and straw yield was recorded under the treatment (T-9) sowing of pearl millet at 60 cm row spacing with ridge and furrow after in cultural operations (i.e. 30 days after sowing). Similarly on pool basis the highest plant height, total tillers, effective tillers, green leaf of plant and percent moisture content in leaf, gross return and B:C ratio was recorded under the treatment sowing of pearl millet at 60 cm row spacing with ridge and furrow after intercultural operations (at 30 days after sowing ) as compare to control plots. This treatment was closely followed by the treatment removal of alternate rows at pre flowering stage of pearl millet (T-6). Whereas lowest plant height, effective tillers , number of green leaves, percent moisture content, grain and straw yield, gross return, net return and B:C ratio was recorded under the control plot where no agronomical management was applied.