Maize productivity in Ethiopia is constrained by a number of problems, variety selection and optimum nutrient levels are the most important in West Showa Zone. The experiment was carried out in Toke Kutaye, West Showa Zone, Ethiopia to enhance maize yield through hybrid varieties and optimum NPS fertilizer rate under smallholder farming conditions. Three hybrid maize varieties namely, BH-546, BH-547 and BH-661 (standard check) were tested along with four levels [(75:75), (100:100), (125:150) and (150:175)] of NPS:Urea Kg ha-1 and control (0:0) was laid out in a Randomized complete block design with factorial arrangement with three replications. Statistical analysis of variance revealed that the main effect of varieties and NPS levels had significant effects on plant height, leaf area, leaf area index, days to 80% tasseling, silking, physiological maturity, grain per cob, thousand grain weight, grain and biomass yield, and harvest index of maize. However, the main effect of NPS levels was not affected days to 50% emergence and plant height at 30 DAP, number of cobs per plant, number of rows per cob and biomass yield were not affected by the main effect of varieties. The highest grain yield (9419.70 kg ha-1) and biomass (16488.10 kg ha-1) of maize were obtained from BH-546 variety with application of 125:150 kg NPS:Urea ha-1. Grain yield correlated strongly and positively with most of the characters, except days to 80% tasseling, silking and physiological maturity. The highest net return (42535.84 ETB ha-1) was obtained from a treatment applied with 125:150 kg NPS:Urea ha-1. Thus, using of BH-546 variety with application of 125:150 kg NPS:Urea ha-1nutrients was found superior both productivity and profitability in the study area and similar agro-climatic conditions.