A two year field experiment was conducted at Plasticulture Farm, CTAE, Udaipur, Rajasthan during rabi season of 2012-2013 and 2013-2014 on sandy loam soil to study the effect of drip irrigation and fertigation on growth, yield, water-use efficiency and economics of cabbage (Brassica oleracea L. var. capitata). The experiment was laid out in factorial randomized block design with ten treatments which included three irrigation levels 100, 80 and 60% of evapotranspiration (ET) along with three fertigation levels, viz., 100, 75 and 50% of recommended dose of fertilizer and one control (Surface irrigation at 1.0 IW/CPE ratio + 100% RDF through farmer's practice) and were replicated thrice. Results indicate that all the growth parameters were significantly influenced by irrigation and fertigation levels. Higher plant height, No of unfolded leaves, diameter of head, volume of head and leaf area index were observed with drip irrigation at 80 % ET and fertigation @ 75 % of RDF. Further highest yield (340.73 q ha-1) was obtained with the treatment combination of drip irrigation with 80 % ET and fertigation @ 75 % RDF. It was found that the treatment combination of drip irrigation with 60% ET and fertigation @75% of RDF noticed maximum water use efficiency (154.76 q/ha-mm) whereas the fertilizer use efficiency was found maximum (193.42 kg/kg of nutrient) with the treatment combination of drip irrigation with 80% ET and fertigation @ 50% of RDF. The maximum uptake of nitrogen (219.20 kg ha-1), phosphorus (56.22 kg ha-1) and potassium (155.05 kg ha-1) by cabbage head were observed with drip irrigation with 80 % ET and fertigation @ 75 % of RDF. Emission Uniformity (EU) of drip system was observed 87.08% during the course of investigation. The maximum benefit-cost ratio (2.31) was estimated in drip irrigation at 80% of ET with fertigation @ 75% of RDF.