A field experiment was conducted during the rabi season of 2010-11 and 2011-12 to evaluate the effect of fertility levels and weed management practices on physiological parameters of wheat (Triticum aestivum L.) at the Research Farm, College of Agriculture, Gwalior. The results revealed that the significantly higher values of plant height and number of leaves were found with the combined application of pinoxaden + carfentrazone-ethyl followed by pinoxaden + metsulfuron-methyl as compare to control and at par with weed free plot. The values of LAI, LAD, CGR and AGR were increasing up to 90 DAS and RGR up to 60 DAS growth stage and then decline up to maturity. However, LAR and NAR were found highest at 30 DAS and decreasing up to maturity stage. The values of dry matter, LAI, LAD, CGR, RGR, NAR and AGR were recorded higher with 125% RDF. The similar trend was observed in LAR up to 60 DAS, but at 90 DAS and maturity stage it was observed higher with 100% RDF. Among the weed control treatments the highest values of LAI, LAD, NAR, CGR and AGR were recorded under weed free plot which was followed by pinoxaden + carfentazone-ethyl and pinoxaden + metsulfuron-methyl at almost all the crop growth stage. However, the maximum values of RGR were noted under weed free plot which was followed by pinoxaden + metsulfuron-methyl and pinoxaden + 2,4-D, whereas, pinoxaden + carfentazone-ethyl and pinoxaden + 2,4-D obtained minimum value of LAR at 90 DAS and maturity stage of crop, respectively. The highest grain and straw yield recorded in weed free plot while minimum in weedy plot. However, the combined application of pinoxaden + carfentrazone-ethyl was found statistically at par with weed free plot in respect of grain and straw yield.