Previous studies demonstrated that the mechanism of sex expression in cucurbits is governed by genetic and environmental factors. The application of plant growth regulators has been found to be effective in initiating higher percentage of female flowers and by their modifying the sex ratio and ultimately resulting in more fruiting in cucurbits. Therefore, the goal of this study was to investigate the influences of gibberellic acid (GA3) and maleic hydrazide (MH) on the basis of growth, yield and quality parameters of musk melon. The results of this investigation revealed that, among different levels of gibberellic acid, significantly maximum growth attributes were contributed with treatment g3 (GA3 30 ppm) whereas the treatment g2 (GA3 20 ppm) was superior on the basis of yield and quality of fruits. Among the different levels of maleic hydrazide, the treatment m2 (MH 100 ppm) performed significantly superior with respect to earliness as well as regarding yield parameters.