A field experiment was conducted during kharif, 2012 on the Agronomy farm of Department of Agronomy, Dr. PDKV, Akola on clay texture soil. The results revealed that plant density of 1,66666 plants ha-1 at spacing (60 x 10 cm) recorded higher gross monetary returns (91088 ` ha-1) but plant density of 1,11111 plants ha-1 at spacing (60 x 15 cm) recorded highest net monetary returns and benefit cost ratio (56950 ` ha-1 and 2.78) and highest uptake of nutrients of N, P2O5 and K2O recorded with plant density of 1,66666 plants ha-1. Whereas, increasing level of fertilizer to 150% recommended dose of fertilizer and land configuration technique of opening furrow 30 days after emergence (DAE) has higher profitability in terms of gross monetary return, net monetary return, and benefit to cost ratio. Similar, trend was also observed in nutrient uptake of N, P2O5 and K2O uptake by plant. Quality parameters of hirsutum cotton were found not to differ significantly due to varied plant density and land configuration, except seed index which was considerably higher (7.27 g) in 150% recommended dose of fertilizer over its lower level of 100% recommended dose of fertilizer.