A field experiment was conducted on a red sandy loam soil (Alfisol) during rabi (maize) and summer (spinach) seasons of 2009-2010 with a view to study the effect of organic manures, inorganic fertilizers and their integration on dry matter production, yield soil nutrient content and uptake maize-spinach cropping system. Among the different combinations application of 75% RDF + 25% through vermicompost recorded significantly the highest dry matter production (vegetative stage and tasseling stage), grain and stover yield (39.84, 61.26, 52.38, 60.77 q ha-1) but, on par with75% RDF + 25% through poultry manure and 75% RDF + 25% through FYM. The spinach crop was grown during summer responded favourably to the residual and cumulative treatments and the highest fresh leaf yield (14.68 and 12.37 t ha-1) was recorded in cumulative and residual treatments. Application of 75% RDF + 25% through VC, PM and FYM to the maize crop showed the highest content and uptake of N, P and K at vegetative, tasseling and at harvesting stages. The highest dry matter production, fresh leaf yield and nutrient uptake of N, P and K by spinach at harvest was recorded in residual and cumulative treatments receiving 100% organic manures.