The present investigation were conducted for two kharif seasons during 2010 and 2011 in the field of Department of Soil Science and Agric. Chemistry, J. N. Krishi Vishwa Vidyalaya, Jabalpur, Madhya Pradesh to study the effect of integrated nutrient management on yield, nutrient uptake, protein content and soil fertility of rice in a Vertisol. The experiment was laid out in a randomized block design with 12 treatments comprising different combinations of inorganic fertilizers, organic manures and biofertilizers were replicated four times. The details of the treatments were T1 = 100% NPK through chemical fertilizers as per STV, T2 = 75% NPK through chemical fertilizers as per STV, T3 = 50% NPK through chemical fertilizers as per STV, T4 = 75% NPK + 5t FYM ha-1, T5 = 75% NPK + BGA + PSB, T6 = 75% NPK + 5t FYM + BGA + PSB, T7 = 75% NPK + Zn, T8 = 75% NPK + 5t FYM ha-1 + Zn, T9 = 75% NPK + 5 t FYM + BGA + PSB + Zn, T10 = 50% NPK + 5t FYM ha-1, T11 = 50% NPK + 5t FYM ha-1 + PSB + BGA, T12 = 50% NPK + 5t FYM ha-1 + PSB + BGA + Zn. Recommended doses of NPK (100% as per soil test value). Zinc sulphate (@ 25 kg ha-1) was applied only to the treatment with Zn. FYM @ 5 t ha-1, BGA and PSB were applied as per required. The results revealed that the substitution of 25% NPK through farmyard manure in recommended dose of NPK along with 5 kg Zn ha-1 and PSB+BGA recorded significantly higher grain yield (39.61 q ha-1) over the 100% NPK treatment (34.88 q ha-1). Maximum nutrients uptake (N, P, K, S and Zn) by rice 75.65, 18.42,120.12, 27.83 kg ha-1 and 231.94 g ha-1, respectively were observed in the treatment receiving 75% NPK+5t FYM ha-1 + PSB + BGA + Zn (T9). The conjunctive use of organic and inorganic fertilizers along with biofertilizers and micronutrients gave highest availability of N, P, K, S and Zn at post harvest soil of rice crops as compared to other treatment combinations. The higher B:C ratio is associated with higher production and better quality of the produce and therefore more economical. It was concluded that the integrated resource management improved the crop yields, produce quality grain as well as the improved the soil fertility. Integrated nutrients applications are more beneficial when the rate of nutrients application is below the normal rate.