A field experiment was conducted during rabi 2009 -10 to study the effect of organic manures in combination with inorganic nitrogen fertilizer on dry matter, yield, oil content and economics of safflower (Carthamus tinctorius L.) in sandy loam soil at Student Farm, College of Agriculture, Rajendranagar (Acharya N.G. Ranga Agricul. University, Hyderabad). The results showed that performance of safflower crop improved significantly with integrated use of inorganic and organic sources of N (FYM/PM/VC) when compared with the application of inorganic N alone. Among the different combinations, application of 50 % N through inorganic fertilizer + 50 % N through vermicompost (T7) resulted in higher dry matter 1451 kg ha-1 at flowering, seed 1239 kg ha-1 and biological yield 1451 kg ha-1 respectively. Similarly, oil yields (361 kg ha-1) in seed at harvest were also recorded with 50 % N through inorganic fertilizer + 50 % N through vermicompost (T7). Seed oil content in safflower was not influenced significantly by different treatments. Highest B:C ratio of 1.83 was recorded with 50 % N through inorganic fertilizer + 50 % N through poultry manure (T8).