A field experiment was conducted during kharif and rabi 2012, at the Wetland Farm of Tamil Nadu Agricultural University, Coimbatore to study the effect of weed management integrated with two different sources of nitrogen on weed control and yield of transplanted rice-rice cropping system. The experiments were laid out in Randomized Block Design with four replications. There were seven treatments with four replication using the rice varieties ADT 43 and CO (R) 50 during kharif and rabi respectively. Observations on growth, yield and nutrient uptake was recorded at 30, 60 DAT and at harvest. The results revealed that application of PE butachlor 0.75 kg/ha + 2,4-DEE 0.4 kg/ha along with 75% inorganic nitrogen +25% organic nitrogen (K)/ pretilachlor 0.75 kg/ha + 2,4-DEE 0.4 kg/ha along with 100% inorganic nitrogen (R) (W3N2) recorded significantly better growth characters viz., plant height and DMP and yield parameters like no. of panicles/m2, total no. of grains/panicle and filled grains percentage. Higher grain and straw yields of rice were obtained with application of butachlor + 2,4-DEE along with 75% I.N + 25% O.N (K) / pretilachlor + 2,4-DEE with 100% I.N (R) (W3N2) and it was comparable with butachlor + 2,4-DEE (both K & R) along with 75% I.N + 25% O.N (K) and 100% I.N (R) (W2N2) during both the seasons. The highest gross and net returns were obtained with application of butachlor + 2,4-DEE along with 75% I.N + 25% O.N (K) / pretilachlor + 2,4-DEE with 100% I.N (R) (W3N2) during both seasons. With regards to B:C ratio, during kharif, application of butachlor + 2,4-DEE (K) / pretilachlor + 2,4-DEE (R) along with 100% I.N (K & R) (W3N1) obtained the highest B:C ratio, whereas, during rabi, the highest B:C ratio was recorded by W3N2.