A field experiment was carried out during kharif and rabi season of 2013-14 and 2014-15 on clayey soil at experimental farm of Department of Agronomy, Vasantrao Naik Marathwada Krishi Vidyapeeth, Parbhani to study the effect of mechanization and non-mechanization practices on growth and yield of soybean (Glycine max L. Merill) – safflower (Carthamus tinctorius L.) seed under varying spacing and nutrient management. The field experiment treatment consists of twelve treatment combinations comprising two practices of mechanization and non-mechanization (sowing, spraying and harvesting) in main plot, two spacing (45 x 5 cm , 60 x 5 cm for soybean and 45 x 20 cm , 60 x 20 cm for safflower in sub plot and three levels of nutrient management (RDF, RDF + foliar application of 0:52:34@ 1.5 kg ha-1 at 35 DAS and RDF + foliar application of 0:52:34 @ 1.5 kg ha-1 at 35 and 55 DAS) in sub-sub plot for soybean in kharif and after that for safflower in rabi season were assigned in a Split-split plot design with three replications. The results of the experiments revealed that application of mechanization practices in soybean-safflower cropping systems recorded significantly higher growth and yield of soybean and safflower than non-mechanization practices under varied row spacing and foliar spray of nutrients with RDF.