Field experiment was conducted to study the effect of nitrogen levels and weed management practices on grain yield of aerobic rice cultivation system at State Agricultural Farm, Rice Research Station, Bankura, under red and laterite zone of West Bengal, during kharif season 2010. Objective of this experiment was to develop suitable agro-techniques for aerobic rice system. The soil of experimental field was sandy loam in texture with medium in fertility status. Lalat variety has yielded maximum (3.10 t ha-1) from treatment N3 (125 kg N ha-1) under aerobic condition. The treatment W3 i.e. pre-emergence application of pendimethalin + Rice: dhaincha (1:1) + 2, 4-D Na salt application (@ 0.80 kg a.i. ha -1) at 25 DAS has recorded excellent performance and contributed to maximum grain yield of 3.96 t ha-1. The interactions were significant and 100 and 125 kg N ha-1, pre-emergence application of pendimethalin + Rice : dhaincha (1:1) + one hand weeding at 60 DAS or 2, 4-D Na salt application (@ 0.80 kg a.i. ha -1) at 25 DAS has contributed to higher grain yield. Pre-emergence application of pendimethalin + Rice : dhaincha (1:1) + one (1) hand weeding or 2, 4-D Na salt application recorded lower weed biomass at 25 DAS of rice. The interactions were significant and 100 and 125 kg N ha-1, pre-emergence application of pendimethalin + Rice : dhaincha (1:1) + one hand weeding at 60 DAS or 2, 4-D Na salt application (@ 0.80 kg a.i. ha -1) at 25 DAS has contributed to higher grain yield.