A field investigation was carried out during rabi season (Pishanam rice) of 2012-2013 at wetland of Central Farm, Agric. College and Res. Instt., TNAU, Killikulam, to investigate the effect of organic and inorganic source of nutrients and biofertilizer on growth and yield attributes, nutrient uptake, yield and economics of transplanted rice (Oryza sativa). There were fourteen treatments laid out in a RB Design and replicated thrice using the rice variety ADT(R) 45. Among the different nutrient management practices, application of GLM @ 6.25 t ha-1 + Azophosmet + 100 % NPK registered significantly the highest growth and yield attributes. The uptake of N, P and K nutrients by rice crop at all the stages of crop growth was remarkably increased by the application of GLM + Azophosmet + 100 % NPK. The grain yield was increased, when GLM was integrated with 100 % NPK application (6030 kg ha-1). The grain yield was further increased, when Azophosmet was applied through seed and soil application along with GLM and 100 % NPK (6617 kg ha-1). However, it was on par with application of FYM + Azophosmet + 100 % NPK. The same trend was noticed in straw yield also. Application of GLM + Azophosmet + 100 % NPK recorded the highest net return of ` 74,108 ha-1 and B:C ratio of 3.63.