An experiment was conducted at new orchard Main agricultural Research station UAS, Raichur during 2014-15 to know the effect of organic manures on growth and yield of papaya Cv. Red lady. Experiment laid out in a Randomized block design with 13 treatments consisting of recommended dose of fertilizers (RDF) combined with organic manures at different combinations and replicated thrice. The vegetative growth parameters such as plant height, stem girth, number of leaves per plant, canopy spread and physiological parameters i.e. leaf area index, light interception and chlorophyll content were influenced significantly due to different treatments. The application of 7.5 kg vermicompost + RDF was found to be beneficial for growth and yield of papaya. The plant height (3.56 m) and stem girth (16.11 cm), number of leaves per plant (39.42), canopy spread (E-W 3.16 and N-S 3.19 m) leaf area index (4.35), light interception (91.14 %) and chlorophyll content (53.81) were maximum with treatment 7.5 kg vermicompost + RDF. Similarly, number of fruits(43.55), fruit diameter(13.46 cm), average fruit weight (1.13 kg), yield per plant (43.75 kg) and yield hectare (132.34 t) were maximum in treatment 7.5 kg vermicompost + RDF. Howerver, highest net return (` 7,03,113.33 ha-1) and benefit cost ratio (3.09) were recorded in the treatment 15 kg FYM with RDF (T3).