A field experiment was conducted to evaluate the agronomic performance and resistance of papaya germplasm against root rot of papaya caused by Fusarium solani. Seven varieties tested were, Pusa dwarf, TFCP-1, TFCP-2, TFCP-3, TFCP-4, Red lady and Pune selection -3. The present study was carried out at Horticultural Research Farm, Rajendra Agricultural University, Pusa, Samastipur (Bihar), India in Randomized block design during 2013-15. The experiment was basically focused on effect of planting seasons and plant spacing on disease incidence, plant height and papaya yield. The disease incidence, plant height and fruit yield were significantly affected by the varieties, seasons of transplanting and spacing. Disease incidence ranged from 69.6 per cent (March-April planting season) to 85.80 per cent (June- July planting season). Pusa Dwarf (88.1%) was found as more susceptible, whereas TFCP-3 (76.1 %) was noted as resistant as the Pusa Dwarf. Among all seven varieties, Pune selection -3 was identified as highest yielder with minimum root rot incidence in March- April planting season over the years. The reduced extant of disease incidence was noted in wider plant geometry (2m x 2m) and March-April planting season, resulting it gave higher yield (71.00 kg/ plant).