Field experiment was conducted during kharif 2015 at College of Agriculture V.C. Farm, Mandya to study the effect of soil and foliar application of micronutrients mixture on soil nutrient status and uptake of nutrients by maize (Zea mays L.) in Alfisols of Southern dry zone of Karnataka in India. The experiment was laid out in RCBD with eleven treatments and replicated thrice. Foliar micronutrient mixtures viz., MM1 (100g ZnSO4, 100g MnSO4, 75g FeSO4, 100g CuSO4 and 50g H3BO3 100L-1) and MM2 (double dose of MM1) sprayed at 30 and 45 DAS and soil micronutrient mixtures viz., MM3 (10kg ZnSO4, 6kg MnSO4, 8kg FeSO4, 4kg CuSO4 and 2kg H3BO3 ha-1) and MM4 (deficient nutrients of Zn and B @ 10 and 2 kg ha-1) applied as basal were tested with control (RDF+FYM) and Standard Fertilizer Practice(SFP) (RDF+FYM+ZnSO4 @ 10kg ha-1). The results revealed that the highest kernel and stover yield of maize (82.00 and 83.67 q ha-1, respectively) were recorded with combined application of soil (MM3) and foliar (MM2) micronutrients mixture along with RDF+FYM and which was significantly higher than that of control and SFP. The per cent increase in kernel and stover yield were 42.2 and 42.6 %, respectively over control and 20.5 and 16.2 %, respectively over SFP. The higher yield was attributed to significant improvement in growth and yield attributing parameters and higher uptake of both micro and macro nutrients by maize.