A field experiment on effect of structured water and fertilizer on growth, yield and quality of grape (Vitis vinifera L.) cv Manjri Naveen was carried out during 2014-2015 at Main Horticultural Research and Extension Centre, University of Horticultural Sciences, Udyanagiri, Bagalkot. The experiment consisted of types of water (structured water and bore well water) and five levels of fertilizer (100, 90, 80, 70, 60 % of the RDF) and was laid out in Split plot design. Among the types of water, structured water recorded significantly the maximum number of panicles (3.60) per cane, panicles (119.60) per vine, bunches (61.50) per vine, weight of bunch (296.06 g), weight of 100 berries (169.98 g) and fruit yield (40.67 t/ha) were recorded. Among the levels of fertilizer, 100% RDF per vine was recorded significantly the maximum number of panicles (4.02) per cane, panicles (121.50) per vine, bunches (62.68) per vine, weight of bunch (316.17 g) per vine, weight of 100 berries (185.89 g), fruit yield (44.07 t/ha). However, the interaction effect between types of water and levels of fertilizer was recorded significantly the maximum berry diameter (15.26 mm), maximum weight of 100 berries (189.33 g) and fruit yield 45.30 t/ha. at Northern dry zone of Karnataka.