Wheat is one of the most important cereal crops and staple food in Ethiopia. However, its productivity is constrained by several problems. Unsuitable seed rate and shortage of improved durum wheat varieties are the most important problems. Hence, a field experiment was carried outin Ucha Kebele in August, 2019 to evaluate effect of four seed rates (100,125, 150 and 175 kg ha-1) on four improved durum wheat varieties (Alemtena, Denbi, Donmateo and Tesfaye) using Randomized complete block design with three replications in factorial arrangement.The results showed that days to 50% heading, days to 90% physiological maturity, days to grain filling, plant height, spike length, total tiller number and thousand seed weight were significantly influenced by main effect of varieties and seed rates but not for their interactions. However, number of seed per spike, grain yield, biomass yield, straw yield and harvest index was significantly affected by varieties, seed rate and their interactions. Effective tiller number and spikelet per spike was significantly affected by seed rate, but main effect of varieties and their interaction werenon significant. The economic analysis revealed that Denb and Donmateovarieties with seed rate of 150 kg ha-1produced maximum net benefit of 35733 ETB and 31575ETB ha-1 and marginal rate of return of 389.60 and 1340%, respectively. Therefore, based on the grain yield and net benefit obtained, variety Denb and Donmateo at seed rate of 150 kg ha-1could be recommended for production in HaroLimu district and other areas with similar agro-ecological conditions.