An investigation on effect of weed management practices in different physiological aspects on wheat crop [Triticum aestivum (L.)] under adoptic and climatic condition of northern part of Madhya Pradesh was carried out during rabi season 2015-16 at the Research Farm, Directorate of Weed Science Research (DWSR), Centre for College of Agriculture (RVSKVV), Gwalior (M.P.). The experiment was laid out in Randomized block design (R.B.D.) replicated three timed with 12 treatments, wheat variety MP4010 was grown up adopting recommended package of practices except weed control measures which were applied as per treatments. The magnitude of weed competition in wheat and weed control through different combination of herbicides had been critically in present investigation for evaluation of different combination of herbicides were growth, yield and yield attributing characters, weed studies and economics of the treatments.The maximum grain, straw, protein yield (kg/ha) was received in application of treatment T11 (two HW at 30 and 60 DAS). It was followed by treatment T6 ((Pendimethalin 1.0 kg/ha fb Sulfosulfuron 0.018 kg/ha). Among all treatment, Pendimethalin 1.0 kg/ha + Sulfosulfuron 0.018 kg/ha gave the maximum net return (? 64921/ha) and B:C ratio (3.02) also.