Appraisal of water and nutrient dynamics in soil-plant continuum is becoming an important issue for availability and optimum utilization of limited water and nutrients for sustainable crop production. To address the problem, a field experiment was conducted during 2013-2015 in the Darjeeling hilly terrain of West Bengal, India to evaluate the effects of 4 irrigation frequency (I1: 15-day interval, I2: 10-day interval, I3: 7-day interval and I4: unirrigated rainfed) and 3 organic manure levels (M0: no-manure, M1: 5 t/ha and M2: 10 t/ha) on growth, yield and yield attributes and water use efficiency of large cardamom (Amomum subulatum Roxb.). The results showed that higher irrigation frequency at 7-day interval and organic manuring @ 10 t/ha in two equal splits, either independently or in combination, significantly increased the plant height, number of leaves and tillers per plant, spike per bunch, capsule per spike and fresh and dry capsule yield over other treatments. Capsule yield attained maximum value of 186.1 kg/ha at 1136 mm water use. Well managed treatment plot (I3M2) was found suitable as compared to other treatments as it required lesser days from bud initiation to 50% flowering (55 days), bud initiation to 50% pod formation (64 days) and likewise bud initiation to harvesting (146 days). Maximum growth, yield attributes, fresh and dry capsule yield (962.48 and 192.09 kg/ha, respectively) and water use efficiency (0.17 kg/ha-mm) were obtained with higher irrigation frequency at 7-day interval coupled with higher organic manuring @ 10 t/ha.