The aim of this study was the analysis of antifungal activity and phytochemical screening of leave extracts of Zanthoxylum armatum for the evaluation of active ingredients. Zanthoxylum armatum belongs to the family of deciduous evergreen shrub and tree, Rutaceae. In the traditional system of medicine various parts of Zanthoxylum armatum are used for the treatment of fevers, dyspepsia, cholera, dental caries, rheumatism, diuretic and stomach ache. The preliminary screening of phytochemicals using soxhlet apparatus for the presence of secondary metabolites from leave extracts have shown the presence of alkaloids, flavanoids, carbohydrate and proteins. The crude extract showed antifungal activity (Disc diffusion method) against Aspergillus fumigatus. None of the extracts showed any inhibitory potential against Candida albicans, Saccharomyces cereviseae and Aspergillus niger. The generated data has provided the basis for its medicinal value and can be used as a therapeutant.