Seven fungicides were tested for their efficacy in reducing the blast disease of finger millet caused by Pyricularia grisea under in vitro and in vivo during kharif 2012-13 and 2013-14 at Agricultural Research Station, Perumallapalle. Among the seven fungicides tested, azoxystrobin 23%EC and tebuconazole 22.9% EC showed complete inhibition of the mycelial growth of the P. grisea at the lowest concentration tested i.e., 5O ppm under in vitro conditions by poisoned food technique. It was evident from the study, that two sprays of tebuconazole (0.1%) at tillering stage was found to be cost effective in controlling the blast disease particularly the neck blast and finger blast which ultimately influence the grain yield. Minimum leaf blast severity of 28.33% was recorded with tebuconazole while azoxystrobin recorded least incidence of neck blast (9.29%) and finger blast (8.33%) followed by tebuconazole with neck blast incidence of 9.60% and finger blast incidence of 9.42% when compared to control with 42.75% (NB) and 43.91% (FB). Maximum grain yield, 38.09 q/ha was obtained in plot treated with foliar spray of azoxystrobin followed by tebuconazole treated plot with grain yield of 37.81q/ha as against the control plot with 22.03 q/ha. However, maximum cost benefit (C:B) ratio of 1:1.80 was obtained in T3 treatment with tebuconazole followed by azoxystrobin with C:B ratio of 1:1.71.