ABSTRACT . The genetics of seed yield, wilt resistance and biochemical traits was investigated through generation mean analysis for four crosses in six generations. Results indicated that developing high yielding wilt resistant hybrids, both the parents should be resistant to wilt. Biochemical constituents viz., total soluble sugar, total phenol, flavonoids, total protein content, and enzyme activity viz., peroxidase and polyphenol oxidase were generally higher in resistant genotypes than susceptible ones under normal and disease inoculated conditions and thus appear to play an important role in imparting resistance against fusarium wilt in castor. Involvement of both additive and non-additive gene actions with preponderance of non-additive gene actions for seed yield, wilt resistance and biochemical traits suggested that hybrid breeding can profitably be utilized for improving seed yield and wilt resistance in castor by exploiting dominance/ non-additive gene action. However, to exploit both additive and non-additive types of gene actions observed for seed yield and biochemical constituents, cyclic method of breeding involving conventional breeding approaches for selection of superior recombinants and their inter se crossing can alternatively be utilized for the development of high yielding, wilt resistant inbred and pistillate lines with desirable biochemical constituents which appear to impart resistance to wilt.