The study area is characterized by tropical/ semi arid and sub humid monsoon type climate with annual rainfall of the region varies from 643-1735 mm, maximum and minimum temperature varies from 30.9- 47.7.0 0C and 7.1 – 21.3 0C respectively. The compound growth rates for area, production and productivity of major crops (paddy, cotton, pigeonpea, soybean, sorghum, wheat and chickpea) and fertilizers utilization for their growth in Nagpur region showed a clear picture that area under Sorghum (54.3 %) and cotton gets shrinking and soybean expands. The production and productivity of soybean improved in period II (1999-2000 to 2008-09) than period I (1989-90 to 1998-99) and the production was 128.2 % and productivity 16.6 % higher over period I in Nagpur region. The slight decrease in area under paddy observed, whereas production and productivity improved in overall period. The contribution of Bhandara district is about 50.3 % and 18 % for production in Nagpur region and Maharashtra State respectively. The compound growth rates of cotton were negative in all cotton growing districts of Nagpur region i.e. Wardha, Nagpur and Chandrapur for area, production and productivity. The consumption of individual fertilizers NPK and its total consumption per annum increased in Nagpur region by 9.75 % and Maharashtra state by about 8.9 % to all India. The improvement in fertilizer NPK consumption pattern was observed with the period i.e 1989-90 (16.29:5.24:1), 1993-94 (8.93:3.55: 1) and 2008-09 (4.74: 2.64:1) as against standard fertilizers NPK consumption ratio 4:2:1, which indicates the development in use of soil testing facilities in the state and increase in awareness of soil health particular in Nagpur region. Further there is need to give more emphasis on consumption of potasic fertilizers in the Nagpur region.