Field experiment was undertaken at the university research farm, Bidhan Chandra Krishi Viswavidyalaya, Mohanpur, Nadia, India during two consecutive summer season to study the effect of irrigation based as soil moisture tension (SMT) and sulphur fertilization on growth, yield, water use and economics of sesame (Sesamum indicum L. var. 'Improved selection No. 5', known as 'Rama') under new alluvial zone of West Bengal. The experiment was laid out in split plot design having four levels of irrigation as main plot and four levels of sulphur (S) fertilization as sub-plot treatment, replicated thrice. Irrigation levels comprised without irrigation (I0), irrigated at 0.35 (atm) atmospheric tension (I1); irrigated at 0.55 atm (I2) and irrigated at 0.75 atm (I3). The sub-plot treatments were: without S (S0), 20 kg S ha–1 (S1), 40 kg S ha–1 (S2) and 60 kg S ha–1 (S3), respectively. Results revealed that vegetative growth and yield attributing characters of sesame were significantly influenced by SMT and sulphur fertilization. Among different levels of SMT, highest vegetative growth was observed with irrigation at 0.35 atm tension but maximum yield components, seed yield, oil content and oil yield were obtained with irrigation at 0.55 atm tension. The highest values of growth characters, yield components and ultimately, seed and oil yield were exhibited with 40 kg S ha-1. Maximum oil content was recorded at 60 kg S ha-1, though it did not differ significantly with former one. CU was maximum (282.50 mm) at 0.35 atm tension and it was decreased with increase in SMT level. WUE was highest (4.16 kg ha-1 mm-1) irrigation at 0.55 atm tension. For seed yield, response of per kg of sulphur application was found to be quadratic in nature and maximum response (7.06 kg seeds per kg of S used) was at 20 kg sulphur level ha-1 and it decreased with increase in S level but the optimum level was found at 29.89 kg ha-1. From the present study it may be concluded that irrigation at 0.55 atm. tension along with application of 40 kg sulphur ha–1 gave the highest economic return and water use than that of other levels of irrigation and sulphur due to favourable effect on growth, yield attributes and yield of sesame in this sub-zone.