The present investigation was carried out to quantify heterosis and inbreeding depression for grain iron and zinc concentrations along with the yield and its contributing traits in two crosses of sorghum with parents distinct for their grain iron and zinc concentrations during post rainy season, 2012-13 at ICRISAT, Patancheru, Hyderabad. Average heterosis was significant for grain yield plant-1 and grain iron concentration in the cross IS13205 × SPV 1359, while most of the traits except plant height and 100-grain weight showed significant average heterosis in the cross IS 13205 × IS 23464 where plant height and panicle length are significant in negative direction and grain iron and zinc concentrations are significant in positive direction. Significant residual heterosis over mid parent was obtained for plant height for both the crosses. Heterobeltiois was negative for almost all the traits studied. Significant negative heterobeltiosis obtained for grain yield for both the crosses and plant height in the cross IS 13205 × IS 23464. Heterobeltiosis was non-significant for grain iron and zinc concentrations in both the crosses. Inbreeding depression was significant for plant height in the cross IS 13205 × IS 23464 and grain iron concentration in the cross IS13205 × SPV1359.