A field experiment was conducted during rabi season 2016-17 and 2017-18 at Research farm, Rajasthan Agricultural Research Institute, Durgapura, Jaipur to determine effects of increase in temperature and elevated concentration of CO2 levels on wheat grain yield and biomass production. Treatments included 0+ 1, 2, 3, 4 and 5oC increase in temperatures and 369, 450, 550, and 650 ppm elevated CO2 levels. Info Crop Wheat model was utilized for simulations and results were used for graphical and statistical analysis. Simulations showed that increasing the temperature by 1 °C from the baseline, there was decrease in grain yield and total biomass by 3.32% and 6.13%, respectively. Further increasing the temperature by 3 and 5 °C from the baseline scenario, the grain yield was estimated to be reduced by 19.17% and 37.72%, respectively. Similarly the estimated biomass yield was reduced by 22.69% and 41.43% under same magnitude change in temperature from the baseline. While, elevated CO2 levels from 369 to 650 ppm, the grain yield of wheat was increased by 9.25%, whereas the biomass yield was increased by 13.27%.