The experiment was conducted during kharif 2016 and 2017 at Tamil Nadu Rice Research Institute, Aduthurai, Thanjavur for studying the effect of different weed management practices on weed characters and yield attributes of mesta. The results revealed that all weed control treatments significantly influenced on plant height, basal diameter and fibre yield compared to unweeded check. The higher fibre yield (24.25 and 21.15 q ha-1 in 2016 and 2017) was recorded with the application of Pretilachlor 50% EC @ 900 ml ha-1 at 45-48 hours of sowing at 45-48 hours of sowing controlled all types of weeds and one more hand weeding is needed after the emergence of weeds and it was at par with two hand weedings and significantly superior over all the other treatments. First nail weeding at 5-6 DAE and second at 10DAE + one hand weeding was also as effective as two hand weedings in respect of fibre yield and controlling the weeds of Mesta. Similarly, higher weed control efficiency with lower weed index was noticed with Pretilachlor 50% EC @ 900 ml ha-1 at 45-48 hours of sowing + one hand weeding followed by two hand weedings treatment which in turn enhanced highest benefit cost. The application of Pretilachlor as pre-emergence herbicide was more effective in controlling the weeds of roselle with highest economic returns.