Evaluated the effect of sulfur and boron on yield, nutrient uptake and quality of safflower grown on sulfur and boron deficient Vertisol (Typic Haplusterts) . Field experiments were conducted at Marathwada Agricultural University, Parbhani, India during rabi seasons of 2008 and 2009. The treatments comprised of three levels of elemental sulfur ( 0,25 and 50 kg ha-1), three levels of boron as borax (0,10 and 20 kg ha-1) and four varieties ( spiny as Sharda and PBNS 12; non-spiny as JSI 97 and JSI 103) . Thus, thirty six treatment combinations were replicated thrice in factorial randomized block design. Standard procedures were adopted for recording the observations, chemical analysis and interpretation of the data. Results revealed significant increase in grain, petal and dry matter yields of safflower with the application of sulfur and boron to the tune of 50 kg elemental sulfur and 20 kg borax ha-1, respectively. Among the safflower varieties, spiny varieties produced more grain and dry matter yields but non-spiny varieties gave more petal yield. Similarly, application of sulfur and boron also increased the uptake of nutrients and improved the quality of produce. Iodine value which is an indicator of degree of unsaturated oil was increased by sulfur and not by boron application.