A field experiment was conducted during the early summer season at Tamil Nadu Agricultural University, Coimbatore, to evaluate the System of Crop Intensification (SCI) practices in sesame. The experiment was laid out in Randomized Complete Block Design, comprised of ten treatments replicated thrice. The results revealed that plant height, number of branches m-2, drymatter, seed yield, stalk yield of sesame were higher at closer spacing of 30 × 30 cm with TIBA application @ 50 ppm at 30 DAS and hand weeding at 35 DAS (T2) compared to control under study. Adoption of SCI practices did not significantly alter the harvest index of sesame. Quality parameters like oil yield was higher under closer spacing of 30 × 30 cm with TIBA application @ 50 ppm at 30 DAS and hand weeding at 35 DAS and higher seed protein content was recorded with wider spacing of 50 × 50 cm with nipping and mechanical weeding at 35 DAS. But, adoption of SCI practices did not alter the oil content of sesame significantly. From the findings of the study, greater uptake of N, P and K was observed with closer spacing of 30 × 30 cm with TIBA application @ 50 ppm at 30 DAS and hand weeding at 35 DAS (T2) than the other treatments imposed in the experiment.