Field experiments were conducted during rabi and kharif season of 2012 and 2013 at northern block of Cotton Research Station, Veppantattai, to study the effect of tillage and weed management methods on weed dynamics and yield of maize under irrigated condition. The experiments were laid out in strip plot design with three replications. Main plot treatment consisted of three tillage methods viz., conventional tillage, minimum tillage and zero tillage. Five weed management methods viz., pre- emergence application of atrazine @ 0.5 kg ha-1 followed by hand weeding on 40 DAS, pre- emergence application of atrazine @ 0.5 kg ha-1 followed by power weeding on 40 DAS, hand weeding twice on 20 and 40 DAS, Power weeding on 20 and 40 DAS along with an unweeded check . sub-plot treatments. Maize seeds of NK 6240 was sown on 60 X 25 cm spacing. Recommended fertilizer dose of 250:75:75 kg NPK/ha for maize was applied in the form of urea, single super phosphate and murate of potash. The results revealed that conventional tillage combined with pre-emergence application of atrazine @ 0.5 kg ha-1 followed by hand weeding on 40 DAS recorded higher weed control efficiency , growth and yield attributes and yield.