To study the impact of treated distillery effluent (TDE) and nitrogen management practices on soil properties and yield of rice (ADT 39), field experiment was conducted at farmer's field, Natham village (M/s EID Parry (I) Ltd.), Nellikuppam, Cuddalore district, Tamil Nadu. The TDE was applied @ 0.5, 1.0, 1.5 lakh lit. ha-1 (main plot treatments), thoroughly mixed and allowed 45 days for natural oxidation. Different levels of N fertilizer viz., 100 per cent Recommended dose of N (RDN), 75 per cent RDN, 50 per cent RDN, 25 percent RDN, LCC 4 based N application and control (without N) were imposed as sub-plot treatments. The experiment was conducted in Split plot design and the treatments were replicated thrice. The results revealed that the nutrients (N, P, K, Zn, Fe, Cu, Mn) availability of the soil were greatly improved by different levels of TDE application. Application of TDE slightly decreased the pH of soil. The TDE application appeared to have promoted the microbial populations and enzyme activities in soil. An increase in grain yield of 14.6, 28.3, 30.3 per cent and straw yield of 21.53, 41.07 and 46.38 per cent were recorded in 0.5, 1.0, 1.5 lakh lit. per ha of TDE applied treatments respectively over control. The yield increase was significant up to 1.0 lakh litres per ha only. The TDE application @ 1.0 lakh lit. ha-1 with LCC based N application was found better in improving the growth, yield attributes and nutrient uptake, which ultimately increased the yield of rice crop. In the LCC based N treatments, the N application has been considerably reduced to the tune of 60, 90 and 90 kg ha-1 in 0.5, 1.0 and 1.5 lakh lit. per ha of TDE applied fields when compared to 100 per cent RDN.