The field experiments were conducted at Annamalai University experimental farm, Annamalinagar to study suitable production technologies to maximise growth parameters and seed yield of sesame during the year 2004-2005. Soil fertility depletion due to inadequate and imbalanced fertiliser use is one of the major factors of stagnation in crop productivity. The experiments were conducted in randomised block design with thirteen treatments replicated thrice. The treatment T12 (Azospirillum seed treatment, RD of NPK, soil application of MnSO4 @ 5 kg ha-1, clipping at (0 + 2) leaf stage and planofix spraying of 30 ppm at 45 DAS and at 55 DAS) registered the highest nitrogen, phosphorous and potassium uptake (79.27, 24.78, 47.57 kg/ha) and highest post harvest soil analysis (207.18, 17.15, 47.57 kg/ha) respectively. Due to highest NPK uptake, the same treatment recorded maximum seed yield of 999.82 kg/ha. Hence, application of Azospirillumas seed treatment, recommended dose of NPK, soil application of MnSO4 @ 5 kg ha-1, clipping at 0 + 2 leaf stage and planofix spraying of 30 ppm at 45 DAS and at 55 DAS found to be best production technologies to improve yield.