The study was conducted in districts of Marathwada region to examine the varibility of major cereals in respect of area, production and productivity. Major cereal crops viz., kharif sorghum, pearl millet, wheat and rabi sorghum and total cereals were selected for study. Time series data for the period from 1985-86 to 2004-05, regarding area, production and productivity were collected from Epitoma of Agriculture, published by Government of Maharashtra. To study the variability in respect of area, production and productivity Cuddy and Della Instability Index (CVt) was worked out. The results of study revealed that as compare with the state level, majority of districts and region recorded higher area, production and productivity variability of kharif sorghum, pearl millet and wheat, except rabi sorghum and total cereals which recorded lower area and productivity variability, respectively during study period. Nanded and Osmanabad District registered highest variability in area, production and productivity of pearl millet and wheat, respectively. The highest area variability of kharif sorghum and rabi sorghum recorded in Jalna and Latur, respectively. The highest production variability of kharif sorghum and total cereals registered in Osmanabad district while it was highest in Latur district for rabi sorghum. The highest productivity variability of total cereals recorded in Latur district whereas it was highest in Osmanabad district for kharif sorghum.