A field experiment was conducted on a sandy loam soil during rabi (maize) and summer (spinach) seasons of 2009-2010 with a view to study the effect of organic manures, inorganic fertilizers and their integration on yield, quality and economics of maize-spinach cropping system. Among the different combinations application of 75% RDF + 25% through vermicompost recorded significantly highest grain and stover yield (52.38, 60.77 q ha-1) at harvest but, on par with75% RDF + 25% through poultry manure and 75% RDF + 25% through FYM. The spinach crop was grown during summer responded favourably to the residual and cumulative treatments and the highest fresh leaf yield (14.68 and 12.37 t ha-1) was recorded in cumulative and residual treatments. Whereas, considering the total cost of cultivation and net returns, the B:C ratio of maize was highest in treatment T5 (100% RDNF) i.e., 2.11, followed by T7 (1.96) and T3 (1.60). However, after harvest of maize, growing short duration crops like leafy vegetables (spinach) both in cumulative and residual treatments increased the B:C ratio. No significant differences were observed in quality parameters in both the crops except the protein content and protein yield.