A field experiment was conducted from kharif 2007 to kharif 2010 on different sites at the research farm of AICRP for Dry Land Agriculture, Sardarkrushinagar (North Gujarat) under arid and semi-arid agro-climatic zone. The different treatments viz., T1: Control, T2: 100 % RDN – urea, T3: 50 % RDN - urea+ 50 % RDN – VC, T4: 50 % RDN - urea+ 50 % RDN –GL, T5: T3+Azotobacter, T6: T4+ Azotobacter, T7: T5+ 8 kg ZnSO4 /ha+ 15 kg FeSO4/ha, T8:T6+ 8 kg ZnSO4 /ha+ 15 kg FeSO4/ha were tried out in sorghum and sesame crop rotation. The results showed that growing of fodder sorghum (GFS 4) and sesame (GS 2) in crop rotation under rainfed condition, application of 40 kg half recommended dose of N (HRD-N) through urea along with 40 kg HRD-N through Gliricidia manuring/ vermi compost with Azotobacter (Azo-8) inoculation as well as addition of 8 kg ZnSO4 /ha and 15 kg FeSO4/ha to sorghum and 20 kg (HRD-N/ha) to sesamum sown as residual crop was found significantly superior for getting higher yield and gross realization, while the highest net income and B:C ratio were recorded under 50 % RDN – urea + 50 % RDN – GL+Azotobacter+8 kg ZnSO4 /ha+15 kg FeSO4/ha of sorghum and sesame crop rotation. Incorporation of Gliricidia leaf manuring as well as vermi compost in soil also improved the fertility status and physical properties of soil.