With the view to integrate use of organic and inorganic fertilizers for sustainable production and maintenance of crop and soil health, a long term investigation was made at the Regional Research Station, B.C. Krishi Viswavidyalaya, Jhargram, West Bengal, India during 2005-06 to 2007-08 on sweet orange cv. Mosambi budded on rough lemon (Citrus jambhiri) rootstock. There were 7 treatment combination based on application of nutrient source per plant per year; viz., T1 : Full recommended dose of N.P.K.; T2 : Neem cake 3 kg; T3 : Cowdung manure 40 kg ; T4 : Vermicompost 5 kg; T5 : Half recommended dose of N.P.K. + Neem cake 3 kg; T6 : Half recommended dose of N, P, K + Cow dung manure 40 kg ; T7 : Half recommended dose of N.P.K. + Vermicompost 5 kg. The experiment was conducted following randomized block design having five replications with four plants in each replication. The results from three consecutive years of study indicated that organic manures along with 50% RDF (recommended dose of fertilizers) was very effective in fruit production and quality improvement in fruits of Mosambi – sweet orange grown in laterite soil under rainfed condition. Application of 5 kg vermicompost or 40 kg FYM combined with 50% RDF resulted in higher fruit production with better plant health in terms of least amount of dry shoot production. These treatments were also helpful for production of quality fruits and better nutrient mobilization from soil to plant as reflected through higher values of NPK in leaves. The soil pH value was near neutral in plots applied with organic manure, while it was acidic in plots where inorganic fertilizers were applied. Nutrient analysis was made from the soil collected from the root rizosphere of individual plant on each plot. The depletion of nutrients from soil in terms of N, P and K was lowest in organic manure applied plants and highest in inorganic fertilizer applied plants.