A field experiment was conducted in alluvial loamy soil at Experimental Farm, Division of Agronomy, IARI, New Delhi during kharif, 2010 to study the integration of diclosulam with cono weeding to manage weeds in. The experiment was laid out in randomized block design and replicated thrice. Two cono weedings at 20 and 40 DAS brought the higher reduction in the growth of all weeds resulting in higher weed control efficiency over all other weed control treatments. Significant effect of weed control measures on crop growth parameters like plant height, no of primary branches, leaf area index and crop dry matter accumulation at all stages of observation. Season long weed free condition brought the higher increase in the yield attributes, seed yield and stover yield of soybean which was statistically similar with two cono weedings at 20 and 40 DAS and pre-emergence application of diclosulam @ 20 g/ha + 1 cono weeding at 30 DAS. Higher net return (` 28450/ha) was obtained in two cono weedings at 20 and 40 DAS closely followed by diclosulam @ 20 g/ha integrated with one cono weeding at 30 DAS (` 28265/ha) and weed-free check treatment (` 27950/ha). Quantitative analysis of soil micro flora showed that herbicidal treatments brought significant change in the population of bacteria, fungi and actinomycetes at 10, 30 days and harvest. Application of diclosulam @ 26 g/ha and diclosulam @ 24 g/ha integrated with one cono weeding at 30 DAS caused the higher reduction in the population of all three microbes at all stages of observation.