A field experiment was conducted during kharif season of 2011 on a sandy loam soil (Alfisol) at Student's Farm, College of Agriculture, Rajendranagar, Hyderabad with a view to study the effect of levels of nitrogen (0, 60, 120 and 180 kg N ha-1) and potassium (0, 30, 60 and 90 kg K ha-1) on soil nutrient (N and K) fractions, pod yield and total nutrient uptake by okra. Randomized Block Design with factorial concept was followed. The pod yield of okra was significantly increased with nitrogen, potassium and their interactions. Among the different interactions (N×K), the highest pod yield (126.17 q ha-1) was recorded by combined application of nitrogen @ 180 kg ha-1 + potassium @ 90 kg ha-1 (N3K3) which was on par with nitrogen @ 180 kg ha-1 + potassium @ 60 kg K2O ha-1 (N3K2). Highest total N (83.83 kg ha-1) and K (75.19 kg ha-1) uptake was recorded with combined application of 180 kg N ha-1 + 90 kg K2O ha-1 (N3K3). Among the different forms of nitrogen and potassium, both NH4-N and NO3-N forms of nitrogen and readily available forms of potassium viz., water soluble K and exchangeable K contributed to pod yield and total N and K uptake, which was evidenced by their significant correlation with these plant parameters.