The long-term fertilizer experiment was started in 2006-07 at Dept. of Soil Science and Agricultural Chemistry, Vasantrao Naik Marathwada Krishi Vidyapeeth, Parbhani to study the effect of manures and fertilizers on yield and soil properties under Soybean-Safflower crop sequence up to 2011-12 on Vertisol (Typic Haplusterts). The results of pooled mean indicated that the 100% NPK + FYM recorded highest grain yield of soybean (2674 kg ha-1) and safflower (1874 kg ha-1) which was statistically at par with 150% NPK, 100% NPK + 25 kg ZnSO4 treatments in both the crops. Maximum straw yield of soybean (3351 kg ha-1) was recorded by the treatment 100% NPK + FYM, where as in safflower (4991 kg ha-1) recorded by the treatment 150% NPK. The highest soybean grain equivalent (4678 kg ha-1) was recorded by the treatment 100% NPK + FYM where as maximum benefit cost ratio (1.93) found in the treatment receiving 150 % NPK followed by 100% NPK + Zn (1.88) and 100% NPK + FYM (1.86). In grain quality parameters protein, oil percentage and oil yield was recorded maximum by the treatment 100% NPK+FYM. Soil properties were improved by the treatment 100% NPK + FYM, as well as FYM @ 10 t ha-1. The soil pH got reduced from its initial value of 8.10 to 8.02 where as organic carbon increased from its initial value 5.50 to 6.60 g kg-1 after sixth years of experimentation due to use of organic manures i.e. FYM @ 10 t ha-1. No addition of fertilizer or manure (control) or application of only nitrogen treatment led to the significant reduction in available sulphur and DTPA Zn in comparison to balanced use of fertilizers and organic manures combined with inorganic fertilizer.