The experiment was conducted during 2011-12 and 2012-13 under the ongoing All India Coordinated Research Project on LTFE with soybean-safflower cropping sequence in Vertisol (Typic Haplusterts) that commenced from 2006-07 at Vasantrao Naik Marathwada Krishi Vidyapeeth, Parbhani. Results showed that the growth attributes (nodulation, height and capsules), productivity and quality of soybean and safflower were significantly influenced by the application of FYM along with 100% NPK. The results revealed that the yield of soybean (26.97 and 23.30 q ha-1, grain and straw respectively) and safflower (18.04 and 48.42 q ha-1, grain and straw respectively) were significantly increased with 100% NPK+FYM@ 5 Mg ha-1 but it was closely followed by the treatments receiving 100% NPK and 100% NPK+ZnSO4@ 25 kg ha-1 which were at par with each other and superior over control (T11). However, the significantly maximum protein (39.72 and 15.17 %), oil (21.18 and 33.86 %) and oil yield (570.92 and 610.47 kg ha-1) of soybean and safflower grain was recorded with the application of conjunctive use of fertilizer and manure i.e. 100% NPK+FYM@ 5 Mg ha-1 than other applications. The highest gross monetary return (GMR), net monetary return (NMR) and return per rupee investment (B:C ratio) of soybean and safflower crop were achieved with the application of 100% NPK+FYM which was significantly superior over rest of the treatments. However, B:C ratio in treatment 100% NPK+FYM was closely at par with that of super optimal dose of fertilizer (i.e. 150% NPK) application. The study also suggested that the balanced use of fertilizers continuously either alone or in combination with organic manure have prominent to sustain productivity, better growth and development of crops.