The leaf curl disease caused by Tomato Leaf Curl Virus affected all 15 tested varieties of tomato during the years 2014-2015 in Tripura. The disease was most severe in BT-1 variety with mean disease 80.9%, while, that was significantly less in the varieties, like, Tura Local, Type-1 and H-24 as well as a hybrid, All-Rounder (Syngenta), with TLCV incidences, 37.5%, 43.3%, 48% and 47.9%, respectively. The disease incidence in 2015 was more than 2014. Similarly, the number of fruits and fruit weight of all tested varieties were less in 2015. The leaf curl disease was not minimized by application of biopesticide namely neem oil, neem leaf extract or neem twig extract. Furthermore, none of the pesticides, like, benfuracarb, carbosulfan, cypermethrin, dimethoate, imidacloprid, malathion and monochrotophos, were much effective to reduce the disease incidence at field conditions in Tripura. However, in case of integrated management practice with the use of seed bed covering by cotton net (mesh ? 0.5mm), applying biopesticide, like, neem (Azadirachta indica) oil (0.3%) at 10 days interval before the appearance of disease in field and spraying chemical pesticide, monocrotophos (0.1%), at 15 days interval soon after appearing of the disease in field was found effective to reduce both incidence and intensity of leaf curl disease and that effect was more promising while host resistance was used in the management practice.