A study was undertaken at College of Agriculture, Vellayani, Thiruvananthapuram to assess the effect of INM on nutritional quality of the grains of finger millet. The field experiment was laid out in Randomised block design with 10 treatments, Replicated thrice. The treatments comprised combinations of five levels of substitution and two levels of biofertilizer (PGPR Mix-I) application. It was observed that among levels of substitution, energy content of the grains was higher (257 Kcal 100g-1) in s1 (100% RDF as inorganic) and s2 (75 % RDN as inorganic + 25 % RDN as vermicompost). Calcium content was significantly higher (331mg 100g-1) in s4 (25 % RDN as inorganic + 75 % RDN as vermicompost). The content of phytate and polyphenols were superior in s1 (638.66mg 100g-1) and s2 (102.67mg 100g-1) respectively. Application of PGPR Mix-I had no significant effect on the nutritional quality of finger millet. Among the interactions, the treatment combination s4b0 (25 % RDN as inorganic + 75 % RDN as vermicompost without PGPR Mix-I) yielded significantly higher calcium in grains (331.34mg 100g-1) and was on a par with s4b1, s3b0, s5b1, s2b1 and s5b0. Crude protein, fat, total dietary fibre, carbohydrates and iron content of the grains were not significantly affected by levels of substitution, biofertilizer and their interaction. The study revealed that integrating organics with inorganics improved the nutritional quality of finger millet in the sandy loam soil of the Southern Laterites of Kerala.